Fenbendazole and/or Mebendazole seem the perfect pairing with insecticide Ivermectin as an off label combination against cancer; recent research shows this 3-in-1 combination attacks the mitochondrial stem cell connection.
I am increasingly asked by cancer patients about the combination of anthelmintic Fenbendazole (FenBen) and insecticide Ivermectin (IVM) against cancer.
Importantly, these patients aren’t the usual stage 2 cancer patients for whom conventional medicine still has a long way to go. These belong to two distinct groups.
* First, there are older patients whose lung cancer, endometrial cancer or prostate cancer has returned since the pandemic and they feel that conventional medicine (which they had before) didn’t work before, so why would it work next time? They subscribe to Einstein’s definition of insanity - doing the same thing over and over again and expecting a different result.
*. Secondly, and this is a bigger group of patients - under 40s with rampant breast cancer, colorectal cancer or lymphoma - the 'early onset' cancer victims. Yes, I did use the word ‘victims’ - this group have ‘turbo cancers’, a new condition not witnessed before the Pandemic or the contaminated vaccines.. Yale Medical School has identified the new group of younger patients; and Albert Bourla, CEO of Pfizer confirmed the existence of Turbo cancer in the Oxford University Interview. We can all have a view on what has caused it. These cancer seem to have none of the classic mutations that patients traditionally had; and no conventional drugs appear to 'work' for them.
Go to: Yale Medicine seeing the growth of Turbo cancer
I have been posting research on off-label drugs since 2007; the first being Low Dose Naltrexone. Then, it was Metformin and Atorvastatin. We’ve covered at least 40 on the CANCERactive Website. I helped my first lady in 2009/10. She had Leukaemia everywhere. She beat her cancer. Please understand, I'm not a Doctor. I do not treat cancer. I'm a scientist that accumulates and reads research. I tell patients what it says, and send them to Doctors for the pills!
The World Health Organisation has not approved Fenbendazole as a treatment for cancer. It is an anthelmintic - it kills worms and fluke and is licensed for animals although much of the research has taken place with humans. Mebendazole is a similar anthelmintic, but licensed for humans. It was used in their anti-cancer protocol by Care Oncology in London. It too is not approved as a cancer treatment by the WHO. Ivermectin is an insecticide, It was approved as such by the FDA who said it was the safest drug they had ever approved. Again, the WHO has not approved it as an anti-cancer drug.
If you don’t want any more chemo or radiotherapy because of the past poor performance and the debilitating side-effects, why wouldn’t you ask about off-label drugs? They generally have few side-effects and because they’ve been around for years, all side-effects are well known. If you have a Turbo cancer and it is not responding to conventional drugs, again, why wouldn’t you ask about off-label drugs?
One problem is that none has a proper Phase III clinical trial behind them. Of course not. Off label drugs are largely off patent and cheap and, worse, could take serious volume and profits away from Big Pharma. So who is going to fund the trials?
An off label protocol that delivers?
In building a protocol the big question is where to start? You need 'an attack dog'. I like the benzimidazoles - especially Fenbendazole and Mebendazole. They yield consistent results - prostate cancer, lung cancer, TNBC, pancreatic cancer, colorectal cancer and more. They block multiple cancer pathways particularly damaging tubulin in microtubes cutting off the energy and food supplies to the worm or cancer cell. These pathways are in almost every cancer cell. And with recent pancreatic cancer and TNBC research there were even pictures in the research showing the disappearance of cancer cells from tumours. But then, I've said all this before; it's nothing new to CANCERactive patients.
Fenbendazole is licensed for animals - Go to review on Fenbendazole
Mebendazole is licensed for humans - Go to review on Mebendazole
Actually, Mebendazole and Fenbendazole, although they belong to the same class of drugs, have slightly differing and complementary benefits. You could even use both, although with slightly different protocols. We have been covering these drugs for over a decade. Fenbendazole was included in the CANCERactive enhanced off label drug protocol. It was also used by 5 doctors at Stanford Medical School when helping patients with kidney cancer and bladder cancer to rid themselves of the disease (see below).
But, it’s not enough to merely knock a tumour back. You need to damage and ideally eradicate the Cancer Stem Cells. The cells that grow back and cause recurrence. Conventional chemo is not very good at this.
A drug that preferentially targets and destroys CSCs? How about Ivermectin. It was approved by the FDA who at the time said it was the safest drug they’d ever approved. In the past I chose Retinoic Acid (in acne drug Accutane) for the same job, but it’s hard to find. I never use Doxycycline because it damages the microbiome and even seems to wake up dormant cancer cells in research from the respected Perelman Institute.
A 2017 research study (contained in my Ivermectin review) showed that while Ivermectin attacked ordinary cancer cells (but not quite as well as Paclitaxel), it preferentially destroyed CSCs and reduced levels of ‘stemness genes’ to a far, far greater extent than the respected chemo drug.
Go to: Off-label Ivermectin attacks cancer in many ways; a Review
As regular readers will know, I have covered research on Ivermectin extensively. It was my 'go-to' for Covid-19 prevention and treatment. I used it myself.
The 3-in-1 protocol or 2-in-1 protocol doses
Although the original clinical approval for Fenbendazole was for intestinal parasites and not for cancer, and it is approved for animal use, the drug has already gone through human clinical trials and so all of the clinical trial work related to toxicity has already been done and Fenbendazole has been deemed safe for human consumption for many years. I did find a regular concern over a liver toxicity issue at high doses, so you must monitor your liver enzymes. However, only one CANCERactive patient has found this liver toxicity issue to date. Normally it's the opposite; one lady in Brisbane Australia having controlled her two cancers by taking 2 gm per day for the past 2 years.
There is a ‘Stanford Medicine Protocol’ from five Doctors at Stanford Medical School - all patients had chemo for their cancers. The FenBen protocol was varied - from 444 up to 1000 mg Fenbendazole, some per day 3 days per week, others per day every day; vitamin E daily 800 mg; Curcumin, 600 mg; CBD oil. All patients became NED (No evidence of disease) within three months. You can follow the reference in the FenBen review (see link above)..
The recommended dose for Mebendazole in humans is 2 x 100 mg daily.
To repeat, most websites suggest Fenbendazole and Mebendazole probably should not be taken continuously over a long period.
The label for the FenBen approval talks of animals not humans. With animals, it is known that there is a likely interaction with salicylanilides like Niclosamide and Dibromsalan, so we suggest you avoid mixing it with either.
Ivermectin was said by the FDA to be the safest drug they'd ever tested, and has a somewhat different action. Some people take 2 mg per 10 kg body weight daily. That rises in Stage 4 cancer to levels of 4 mg per 10 kg of body weight.
Research, and experts, suggest the combination drugs should be used normally for 2-3 months and up to six months and can be used with or without chemo.
In my opinion, you should use the drugs with berberine 3 x 500 mg (not metformin because it is inconsistent and also raises cancer-promoting homocysteine levels). You might also use Honokiol to block angiogenesis and Modified Citrus Pectin to block Galectin-3 which causes cancer spread and drug resistance.
Is there any research for the 3-in-1 protocol?
There is now a peer-reviewed study from 15 top US Doctors who analysed all three drugs Fenbendazole, Mebendazole and Ivermectin. Experts believe this combination attacks the mitochondrial support for cancer stem cells (1).
All other research references are in the three articles.
Personally I would choose FenBen over MBZ, and put IVM with it.
The key issue is 'at what doses' and a multitude of US websites are all over the place on this. Total inconsistency. We have researched this extensively and put together a flexible plan depending upon the patient, their age, cancer and condition.
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NB. At CANCER active, we strongly suggest you do NOT try to put a protocol together on your own. You could always talk to Chris Woollams first on [email protected].
We note that these off label drugs and/or this blog was featured by FLCCC and on the Joe Rogan with Mel Gibson podcast and the volume of enquiries swamped him. Chris does a fantastic job helping people with cancer build a body conducive to health - we see most of the incoming e-mails on patient successes. You can read what patients think about what he does here - https://www.canceractive.com/article/personal-prescription-feedback-and-comments
Go to: The CANCERactive enhanced off-label drug protocol
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References
1. Targeting the mitochondrial stem cell connection in cancer treatment; a hybrid orthomolecular protocol: ilyes Baghli, William Makis, Paul E Marik et al; Journal of Orthomolecular Medicine September 19, 2024